Figure 1. Patients with Alagille syndrome exhibit sporadic spontaneous and provoked hemorrhages, with sex differences.

1. Systematic review search strategy following PRISMA guidelines. For detailed flow chart see Appendix Supplementary Methods. ALGS, Alagille syndrome; PAS, pulmonary artery stenosis.
2. Schematic depicting intracranial bleeds (n = 24, Binominal test in 9 males vs 15 females, ns, P = 0.2295). They were reported as a consequence of either minor head trauma or coagulopathy, or they were spontaneous (pie charts denote reported patient numbers). Pie chart depicting the number of spontaneous intracranial bleeds (male n = 1, females n = 10, Binominal test *P = 0.0117). For details of intracranial bleeds and references, see Table 1.

Source data are available online for this figure.