Skip to main content
. Author manuscript; available in PMC: 2022 Dec 7.
Published in final edited form as: Reprod Toxicol. 2019 Oct 7;91:1–13. doi: 10.1016/j.reprotox.2019.10.001

Table 2.

Upstream regulator analysis (Ingenuity Pathway Analysis) for DMSO (96 h versus 6 h) and 0.1 μM at 96 h. Only the top predicted upstream regulators are shown (six for DMSO and three for 0.1 μM ATRA at 96 h). Upstream regulators that were not assigned a predicted activation state are omitted from this table.

Concentration Upstream Regulator Expr Log Ratio Predicted Activation State Activation Z-Score P-value of Overlap
DMSO (96 h v 6 h) progesterone Activated 2.148 1.33E-15
DMSO (96 h v 6 h) EOMES 6.906 Activated 3.685 7.46E-15
DMSO (96 h v 6 h) SOX2 0 Inhibited −2.731 7.95E-14
DMSO (96 h v 6 h) topotecan Inhibited −3.923 1.85E-12
DMSO (96 h v 6 h) dexamethasone Activated 3.013 4.58E-12
DMSO (96 h v 6 h) tretinoin Activated 2.51 1.01E-11
0.1 μM (96 h) EOMES −1.017 Inhibited −2.549 1.22E-15
0.1 μM (96 h) dexamethasone Inhibited −2.512 1.62E-13
0.1 μM (96 h) LHX1 −2.049 Inhibited −2.774 2.81E-11