Fig. 2.
Effect of Lactobacillus sakei S1 on macroscopic disease (A), colon length (B), colonic MPO activity (C), body weight (D), and colon histology (E) in TNBS-induced colitis in mice. TNBS, except in the normal control group, was intrarectally administered to mice and test agents [saline, L. sakei S1 (1 × 108 or 1 × 109 CFU/ mouse), or sulfasalazine (SLZ; 50 mg/kg)] were orally administered for 3 days. The mice were anesthetized and sacrificed 20 h after the final treatment with LAB. All values are represented as mean ± SD (n = 6). #Significantly different compared to the normal control group (p < 0.05). *Significantly different compared to the group treated with TNBS alone (p < 0.05). Scale bars: 50 μm.