Fig. 4.

Percent inhibition of HSV-1 following incubation of virus with bioactive compounds. HSV-1 and the bioactive compound, valacyclovir or (20)S-Rg3, were applied directly to cells simultaneously (no incubation) or the virus and compound were incubated together for 1 h or 4 h prior to being added to the cells. A significant difference exists between the incubation of HSV-1 and 20(S)-Rg3 for 4 h compared with no incubation, p < 0.05. No differences existed for incubation of HSV-1 and valacyclovir.