Table 2.
Antiviral activity (IC50), cell toxicity (CC50), and selectivity index (SI) of 21 compounds selected by the secondary screening with remdesivir as a positive control.
| Drug name | IC50 (µM) | CC50 (µM) | Selectivity Index (SI) |
|---|---|---|---|
| Amodiaquine | 4.6 | >50 | >10.9 |
| Micafungin | 12.9 | >50 | >3.9 |
| Tiratricol | 4.6 | >50 | >10.9 |
| Loperamide hydrochloride | 14.8 | >50 | >3.4 |
| Thioproperazine dimesylate | 13.4 | 41 | 3.1 |
| Selexipag | 8.5 | >50 | >5.9 |
| Imatinib | 13.9 | >50 | >3.6 |
| Asenapine | 13.3 | >50 | >3.8 |
| Quinidine gluconate | 24.2 | >50 | >2.1 |
| hydroquinidine | 23.8 | >50 | >2.1 |
| Masitinib | 14.9 | 47.1 | 3.2 |
| Vinpocetine | 8.6 | >50 | >5.8 |
| Diphenylpyraline hydrochloride | 42.4 | >50 | >1.2 |
| Reserpine | 29.2 | >50 | >1.7 |
| NKH 477 | 12.7 | >50 | >3.9 |
| Promethazine hydrochloride | 19.1 | >50 | >2.6 |
| Ethopropazine hydrochloride | 20.3 | >50 | >2.5 |
| Eltrombopag | 2.0 | 43.8 | 21.9 |
| Vemurafenib (PLX4032) | 7.0 | >50 | >7.1 |
| Bromhexine hydrochloride | 14.4 | >50 | >3.5 |
| Dibucaine hydrochloride | 21.6 | >50 | >2.3 |
| Remdesivir | 5.0 | >50 | >10 |