Fig. 4. Sensibility, synergistic effects, and reduction in melanization of the mycelial form of the Sporothrix spp. clinical strain LSASs01 in the presence of Ag-HPA salts and antifungal drug disks by the diffusion agar method.

(A1) Untreated control; (A2-A5) Growth in the presence of Ag-HPA salts Ag₃[PMo₁₂O₄₀], Ag₃[PW₁₂O₄₀], Ag₆[SiW₁₀V₂O₄₀], and Ag₄[SiW₁₂O₄₀], respectively; (B1) Growth in the presence of amphotericin B (AMB); (B2-B5) Growth in the presence of combinations of AMB and Ag-HPA salts; (C1) Growth in the presence of itraconazole (ITC); (C2-C5) Growth in the presence of a combination of ITC and Ag-HPA salts. Figures correspond to 15 days (inferior small plates) and 30 days (superior big plates) of incubation.