. 2022 Dec 7;14(1):e12383. doi: 10.1002/dad2.12383

TABLE 2.

Trajectories of change in cognitive outcomes and CSF biomarkers of AD as a function of the KLOTHO KL‐VS polymorphism

VARIABLE		ESTIMATE	SE	t	p
COGNITIVE OUTCOMES ^a
RAVLT Trials 1–5	Age	–0.12	0.03	–3.45	0.001
	KLOTHO	–0.32	0.82	–0.39	0.69
	Age x KLOTHO	–0.07	0.07	1.09	0.27
RAVLT Long Delay	Age	–0.04	0.01	–3.20	0.001
	KLOTHO	–0.34	0.28	–1.23	0.22
	Age x KLOTHO	–0.0006	0.02	–0.03	0.97
TMT A	Age	–0.002	0.04	–0.07	0.95
	KLOTHO	–0.03	0.90	–0.03	0.97
	Age x KLOTHO	–0.03	0.07	–0.39	0.70
TMT B	Age	0.64	0.09	6.42	<0.001
	KLOTHO	1.22	2.56	0.48	0.63
	Age x KLOTHO	–0.16	0.19	–0.85	0.39
CSF BIOMARKERS ^b
Aβ42	Age	–4.16	2.22	–1.79	0.07
	KLOTHO	–26.52	35.99	–0.74	0.46
	Age x KLOTHO	–5.46	5.57	–0.99	0.33
t‐Tau	Age	5.35	1.31	4.08	<0.001
	KLOTHO	–33.35	24.17	–1.38	0.17
	Age x KLOTHO	–4.09	3.06	–1.34	0.18
p‐Tau	Age	0.49	0.18	2.93	0.004
	KLOTHO	–1.78	2.56	–0.69	0.49
	Age x KLOTHO	–1.78	0.40	–2.26	0.02
t‐Tau/Aβ42	Age	0.01	0.002	5.33	<0.001
	KLOTHO	–0.06	0.05	–1.23	0.22
	Age x KLOTHO	–0.006	0.006	–1.03	0.31
p‐Tau/Aβ42	Age	0.001	0.0003	4.23	<0.001
	KLOTHO	–0.004	0.005	–0.76	0.45
	Age x KLOTHO	–0.001	0.001	–1.42	0.16

KLOTHO denotes the estimated mean difference at age 0 (mean age for the whole sample) in the outcome of interest between KL‐VS^NC and KL‐VS^HET. Age indicates the annual rate of change in the outcome of interest for KL‐VS^NC. Age x KLOTHO denotes the difference in the annual rate of change between KL‐VS^NC and KL‐VS^HET (this estimate must be added to the estimate for age to determine annual rate of change for KL‐VS^HET).

Abbreviations: KL‐VS^NC = KL‐VS non‐carriers; KL‐VS^HET = KL‐VS heterozygotes; RAVLT = Rey Auditory Verbal Learning Test; TMT = Trail Making Test, Aβ42 = amyloid beta 42; t‐Tau = total tau; p‐Tau = phosphorylated tau; SD = standard deviation.

^{^a}

Covariates: APOE ε4, sex, parental history of AD, education.

^{^b}

Covariates: APOE ε4, sex, parental history of AD.