TABLE 2.
PK parameter estimates and results of bootstrap analysis for the final model.
| Parameter | NONMEM | Bootstrap | Bias (%) | |||
|---|---|---|---|---|---|---|
| Estimates | RSE (%) | Shrinkage (%) | Median | 95% CI | ||
| θCL (L/h) | 11.7 | 7.4 | — | 11.38 | 9.06–13.4 | −2.72 |
| θV (L) | 811 | 11.1 | — | 822 | 616–1,025 | 1.42 |
| θALB (g/L) | 1.60 | 27.4 | — | 1.55 | 0.690–2.55 | −3.11 |
| θeGFR (ml/min) | 0.476 | 50 | — | 0.501 | 0.229–1.40 | 5.21 |
| ηCL (%) | 38.6 | 16.5 | 35 | 36.2 | 17.9–49 | −6.17 |
| ηV (%) | 53.7 | 13.2 | 31 | 51.9 | 23.6–71.0 | −3.34 |
| ε1 (%) | 18.3 | 14.5 | 36 | 17.8 | 9.04–25.0 | −3.03 |
| ε2 (μg/ml) | 0.122 | 41.3 | 36 | 0.119 | 0.0207–0.198 | −2.33 |
Note: θCL, The population parameters typical value of clearance; θV, The population parameters typical value of the volume of distribution; θALB, The population parameters typical value of ALB; θeGFR, The population parameters typical value of eGFR; ηCL, Inter-individual variation in clearance; ηV, Inter-individual variation in the volume of distribution; ε, Residual variation; CI, Confidence interval; RSE, relative standard error; Bias, prediction error; Bias% = (Bootstrap Median–NONMEM Estimates)/NONMEM Estimates × 100%.