FIG. 4.

Protective efficacy of vaccines in mice challenged with different doses of L. mexicana. C57BL/6 mice were vaccinated with a mixture of the three recombinant antigens and IL-12 or Detox as adjuvants as described in Fig. 2 and challenged with 4 × 10⁵ (A) or 2 × 10⁶ (B) L. mexicana promastigotes. Lesions were scored as in Fig. 2, and data represent the average values of five mice per group. Error bars are shown for representative groups and correspond to the mean ± the SD.