TABLE 3.
Surface phenotypea of cells from DQ8+ transgenic mice and DQ8− littermates
| Cellsb | % of cells positive for indicated surface phenotypec
|
||||
|---|---|---|---|---|---|
| CD4 | CD8 | B cell | HLA-DQ | I-Ab | |
| DQ8+ mice | |||||
| LNC | 18.1 | 44.2 | 31.1 | 28.4 | 2.1 |
| Activated LNC | 33.3 | 54.4 | 22.0 | 13.8 | 5.0 |
| SPC | 12.1 | 17.2 | 37.2 | 38.0 | 4.2 |
| Activated SPC | 18.2 | 36.6 | 27.1 | 27.2 | 3.5 |
| DQ8− mice | |||||
| LNC | 5.3 | 75.2 | 17.3 | 0.1 | 0.6 |
| Activated LNC | 4.7 | 90.6 | 18.4 | 0.9 | 2.4 |
| SPC | 4.9 | 15.5 | 33.4 | 0.02 | 1.4 |
| Activated SPC | 5.0 | 33.8 | 30.5 | 0.05 | 1.8 |
a
Data were averaged from two independent experiments.
b
Activated LNC and SPC were cultured with ABRA#14 for 4 days.
c
Values in boldface represent an increase compared to the corresponding values for nonactivated cells.