Figure 3.

BC cell-derived exosomes induced proliferation, invasion, and migration of HMFs and expedited HMF switch to CAF phenotype. In HMFs uptaking exosomes from miR-425-5p inhibitors transfected MDA-MB-231 and BT549 cells, the cell proliferation (a, b), invasion (c, d), and migration (e, f) were detected by clone formation, Transwell, and scratch-wound assays. Experimental data presented as means ± standard deviation. Experiment was repeated 3 times. ^∗∗P < 0.01 compared with the control group. ^##P < 0.01 compared with the exo_miR-NC inhibitor group.