Figure 4.

BC cell-derived exosomes induced protein expression to expedite HMF switch to CAF phenotype. In HMFs uptaking exosomes from miR-425-5p inhibitors transfected MDA-MB-231 and BT549 cells, the expression of α-SMA and FAPα (a), CXCL1, TGFβ1, and IL6 (b), P21, P27, and Ki67 (c), and vimentin, E-cadherin, N-cadherin, α-catenin, fibronectin, and MMP2 (d) were detected by RT-PCR and western blot assays. Experimental data presented as means ± standard deviation. Experiment was repeated 3 times. ^∗∗P < 0.01 compared with the control group. ^##P < 0.01 compared with the exo_miR-NC inhibitor group.