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. 2022 Nov 30;2022:5266627. doi: 10.1155/2022/5266627

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Copyright © 2022 Yue Zhu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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TGFβ1 promoted ROS production to promote HMF switch to CAF phenotype. siRNA-TGFβ1 and overexpression-TGFβ1 were transfected into HMFs; the expression TGFβ1 (a, b), α-SMA and FAPα (c), and CXCL1, IL-8, and IL-6 (d) were detected by RT-PCR and western blot assays. (e) Venn analysis of overlapping genes. (f) A PPI network based on STRING website. (g) ROS level. Experimental data presented as means ± standard deviation. Experiment was repeated 3 times. ^∗∗P < 0.01 compared with the NC-KD group. ^##P < 0.01 compared with the NC-OE group.