Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 21;54(12):1786–1794. doi: 10.1038/s41588-022-01208-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 8 — AD vs Age association: Sensitivity analysis of the gene burden tests (for the most significant deleteriousness thresholds, Table 2) for the mega-analysis dataset (RIN3, CLU, ZCWPW1, ACE: without exome-extracts) (respectively n = 31,905 and n = 29,727 unique individuals). Comparison of the case/control odds ratio of an age-matched and a non-age-matched analysis. Age-matching was performed as described in the methods. Based on the confidence intervals, we cannot exclude that the signals in ACE, ADAM10 and ZCWPW1 are affected by other age-related conditions. Note however, that the signals in ADAM10 and ZCWPW1 are based on very few variants, such that confidence intervals are expected to be wide.