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. 2022 Nov 21;54(12):1786–1794. doi: 10.1038/s41588-022-01208-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — Sample population compared to 1,000 G population samples. First two PCA components of the study samples used for the Stage 1 and Stage 2 analysis, shown in context of the 1000 Genomes samples for reference (see Supplementary Note section 1.3.4). Samples in red are considered population outliers. Samples with only exome-extracts were not included in this analysis.