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. 2022 Nov 10;24(12):1692–1700. doi: 10.1038/s41556-022-01021-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — (A) Genes correlated with Krt10 expression in the early stages of differentiation (bins 2, 3 and 4). Shown are all genes with a pearson correlation > 0.3. (B) Identified transcription factors that target at least one of the Krt10-correlated genes and their corresponding targets (top 30, importance >10). Transcription factors highlighted in green were selected for plotting in (C). (C) Plots showing expression patterns of selected transcription factors and their putative target and/or co-regulated genes from Scenic analysis. Transcription factors were selected by their target gene expression patterns and literature search. Panels show the expression of the transcription factor overlaid on UMAP (left), differentiation-related target gene expression score overlaid on UMAP (middle-left), violinplot of differentiation-related target gene expression score grouped according to differentiation bins (middle-right), and dotplot of top 30 (or all for Cebpb) target gene expression patterns (right). Dot plot genes were ordered according to their importance as a target gene for the transcription factor. Differentiation-related target genes were defined as genes that were not identified as differentially expressed in bin 1. (A-C) plots show integrated results from all biological replicates from all datasets (Joost 2016 n = 19, ITGA6-sorted n = 2, Joost 2020 n = 5 mice).