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. 2022 Sep 29;54(12):1827–1838. doi: 10.1038/s41588-022-01182-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — (a) Heatmap reporting geneset enrichment analysis in the UMAP clusters identified in main Fig. 7b. Test Genesets were derived from 2,086 different tissue and cell types including bulk RNAseq of mouse normal tissues and tumours, huCTC signatures, and mouse and human intestinal stem and mature cell signatures (see Methods). (b) ZSG immunohistochemistry of aged Pdx1^RNalcn^+/+ (top left) and Pdx1^RNalcn^Flx/Flx (bottom left) mouse lung bronchioles (scale=100um). Right, the number of ZSG⁺ cells/bronchiole in the lungs of Pdx1^RNalcn^+/+ (n = 2 mice, 6 lung lobes, 121 bronchiole) and Pdx1^RNalcn^Flx/Flx (n = 1 mouse, 4 lung lobes, 57 bronchioles). (bar=median; **p = 0.0051 two-tailed Mann-Whitney U Test). (c) Two-photon direct ZSG⁺ cell clusters detected in entire lung section of a Pdx1^RNalcn^Flx/Flx mouse. (d) Exemplar co-immunofluorescence of tail vein injected P1^RNalcn^Flx/Flx ntCZCs (arrows) incorporated into the organs of recipient mice (arrows indicated ZSG⁺ cells, scale bar=50um).

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