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. 2022 Sep 29;54(12):1827–1838. doi: 10.1038/s41588-022-01182-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — Fibrosis-free survival for all organs (a) or the indicated organs (b-i). P value reports the log-rank statistic (Mantel-Cox). The numbers of animals of each genotype are shown. p-values for each graph comparing P1^RNalcn^+/+ and P1^RNalcn^+/Flx and P1^RNalcn^+/+ and P1^RNalcn^Flx/Flx, respectively: All organs (0.0664, 0.0035), Kidneys (0.0037, 0.0022), Skin (0.1195, 0.0569), Lungs(0.3791, 0.1000), Liver(0.8846, 0.7250), Stomach(0.4938, 0.4225), Small intestine(>0.9999, 0.2348), Large intestine(0.1312, 0.2655), Pancreas(0.4764, 0.7571). (j) Photomicrographs of haematoxlin and eosin (H & E) and Picro-Sirus Red stain and co-immunofluorescence of ZsGreen, alpha-smooth muscle actin (ASMA) and Dapi in kidney from P1^RNalcn^+/+ and P1^RNalcn^Flx/Flx mice aged >400 days. Note in P1^RNalcn^Flx/Flx kidney: extensive fibrosis below the hashed line (H & E); marked Picro-Sirius Red staining indicating extensive fibrosis; ZsGreen recombination, gross distortion of normal kidney architecture and extensive alpha-SMA expression. (k) Photomicrographs of H & E stained skin from P1^RNalcn^+/+ and P1^RNalcn^Flx/Flx mice aged >400 days. Note in P1^RNalcn^Flx/Flx skin: ulceration and thickening of cornified layer, marked thickening of squamous cell layer and fibrosis of dermal layer. (scale 100um).