Extended Data Fig. 2. Genetic architecture of 897 association signals for CAD.

Minor allele frequency versus per-allele odds ratio for CAD for all sentinel variants reaching genome-wide significance or the 1% FDR threshold in our study. Colored circles indicate genome-wide significant associations (P < 5.0 × 10⁻⁸) with sentinel variants that are not correlated (r² < 0.2) with a previously reported variant (red), genome-wide significant sentinel variants correlated with a previously reported variant (blue), and associations reaching the 1% FDR threshold (P < 2.52 × 10⁻⁵) in our meta-analysis (gray). Two-sided P values are from Z-scores from fixed-effect inverse-variance weighted meta-analyses.