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. 2022 Dec 5;54(12):1881–1894. doi: 10.1038/s41588-022-01236-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — (a) Boxplot depicting TAM proportions in all tumor and normal cells profiled by scRNA-seq and grouped by adult and pediatric sample groups across N = 16 biologically independent samples. The median is marked by the thick line within the boxplot, the first and third quartiles by the upper and lower limits, and the 1.5x interquartile range by the whiskers. (b) Distributions (mean values + /− 2xSEM) of macrophage and microglia proportions within TAMs across N = 16 pontine and thalamic tumors. (c) & (e) Venn diagram depicting shared and specific OPC-like-to-myeloid (c) and myeloid-to-OPC-like (e) ligand-receptor interactions between different OPC-like subpopulations. (d) & (f) Ligand-receptor interactions assessed for each OPC-like subpopulation for OPC-like-to-myeloid (d) and myeloid-to-OPC-like (f) interactions. Color scale depicts probabilities of interaction, while dot size denotes Benjamini-Hochberg (BH)-corrected p-values from a two-sided permutation test.