Table 2.
Mediation effect of serum SHBG on the association between IHL content and type 2 diabetes
| Model | Men (n=810) | Women (n=744) | ||
|---|---|---|---|---|
| OR (95% CI) | Proportion mediated (95% CI)a | OR (95% CI) | Proportion mediated (95% CI)a | |
| Crude | ||||
| Total effectb | 1.12 (1.08, 1.17) | 1.08 (1.04, 1.14) | ||
| Direct effectb | 1.10 (1.06, 1.15) | 1.04 (1.01, 1.09) | ||
| Indirect effectb | 1.02 (1.01, 1.03) | 17.2 (9.6, 27.6) | 1.04 (1.02, 1.07) | 50.9 (26.7, 81.3) |
| Model 1 | ||||
| Total effect | 1.13 (1.09, 1.17) | 1.08 (1.05, 1.13) | ||
| Direct effect | 1.10 (1.06, 1.14) | 1.04 (1.01, 1.09) | ||
| Indirect effect | 1.03 (1.02, 1.04) | 24.6 (15.6, 36.0) | 1.04 (1.02, 1.07) | 48.5 (24.0, 80.4) |
| Model 2 | ||||
| Total effect | 1.08 (1.05, 1.13) | 1.04 (1.00, 1.09) | ||
| Direct effect | 1.07 (1.03, 1.11) | 1.02 (0.98, 1.07) | ||
| Indirect effect | 1.01 (1.01, 1.02) | 17.7 (8.3, 32.8) | 1.02 (1.00, 1.04) | 42.6 (2.5, 254.1) |
| Model 3 | ||||
| Total effect | 1.04 (1.00, 1.10) | |||
| Direct effect | 1.02 (0.98, 1.07) | |||
| Indirect effect | 1.02 (1.01, 1.04) | 55.9 (−72.38, 337.2) | ||
Model 1 was adjusted for age; model 2 was additionally adjusted for BMI, alcohol intake, DHD-13, level of education and total physical activity; model 3 was additionally adjusted for menopausal status and use of oestrogen-containing medication in women
aThe proportion mediated (%) is calculated as ORDirect × (ORIndirect − 1)/(ORDirect × ORIndirect − 1) × 100
bTotal effect represents association between IHL content and type 2 diabetes status; direct effect represents association between IHL and type 2 diabetes status not attributable to serum SHBG; indirect effect represents association between IHL and type 2 diabetes attributable to serum SHBG (mediation)