Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 8;7:69. doi: 10.1038/s41536-022-00265-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — a KEGG analysis of bulk RNA-seq at different induction points. b The transcription factor SOX9, condylar chondrocyte anabolism markers COL2A1 and COL1A1, and the catabolism marker MMP13 were obviously upregulated 3 days after the removal of CHIR99021. c An obvious downregulation of β-catenin was detected by western blotting 7 days after the removal of CHIR99021. d The chondrogenic transcription factors SOX9 and RUNX2 were decreased, as well as COL2A1 and OPN, while MMP13 was enhanced in the presence of CHIR99021 in N2B27. e A scheme for the Wnt signalling pathway involved in chondrogenic differentiation of ECCs.