TABLE 2.

Dysregulated circRNAs and their function in AML.

CircRNA	Expression	Molecular mechaism	Biological function	References
Circ_00059707	Down	Regulaing miR-1287-5p	Regulation of cell growth and apoptosis	Ma et al. (2022)
Cir_POLA2	Up	Regulating miR-34a	Regulation of cell proliferation	Li H. et al. (2021)
CircSPI1	Up	Sponging miR-1307-3p/miR-382-5p/miR-767-5p	Oncogene, regulation of cell proliferation and apoptosis	Wang X. L. et al. (2021)
Hsa_circ_0012152	Up	Regulating miR-625-5p/SOX12 axis	Regulation of cell proliferation and apoptosis	Shang et al. (2021)
Hsa_circ_0002483	Up	Regulating miR-758-3p/MYC axis	Regulation of cell proliferation and cell cycle arrest and apoptosis	Xiao et al. (2021)
Circ_PTK2	Up	Regulating miR-330-5p/FOXM1 axis	Regulation of cell proliferation and apoptosis	Yi et al. (2021)
Hsa_circ_0121,582	Down	Regulation of miR-224/GSK3β	Inhibition of cell proliferation	Chen et al. (2020)
Hsa_circ_0000370	Up	Regulating of miR-1299 and S100 calcium-binding protein A7A protein	Regulation of cell viability and apoptosis	Zhang L. et al. (2020)
CircRNA RNF13	Up	Regulating miR-1224-5p	Regulation of cell proliferation, migration and apoptosis, and cell cycle progression	Zhang R. et al. (2020)
Hsa_circ_0009910	Up	Regulating miR-20-5p	Regulation of cell proliferation and apoptosis	Ping et al. (2019)
Hsa_circRNA-100290	Up	Regulation of miR-203/Rab10 axis	Regulation of cell proliferation and apoptosis	Fan et al. (2018)
Circ-DLEU2	Up	Regulating of miR496/PRKACB axis	Regulation of cell proliferationn and apoptosis	Wu et al. (2018)
CircSPI1	Up	Regulating Eif4AIII and PU.1	Regulation of myeloid differentiation of AML cells	Wang X. L. et al. (2021)
CirPLXNB2	Up	Regulation of PLXNB2, BCL2, cyclin D1 and BAX	Regulation of cell proliferation, migration and apoptosis	Lin et al. (2021)
CircMYBL2	Up	Upregulation of FLT3 translation	Regulation of cell proliferation and apoptosis, and cell cycle progression	Sun et al. (2019)
CircBCL11B	Up	NA	Regulation of leukemic cell proliferation	Lux et al. (2021)