Fig. 4. Independent testing of biomarkers of response to paclitaxel.

A Immunohistochemical staining of filamin A from patients with H-scores in the upper (Q1, left) and lower (Q4, right) quartiles. Scale bars: 100 µm. B Comparison of pCR rates for patients in the Q1 versus Q2-4 subgroups among the whole Set-1 series (N = 117) or divided by subtype (HR+: Hormone-positive, N = 62; HER2: HER2-amplified, N = 35; TNBC: triple-negative breast cancer, N = 20), according to the staining of p-P70S6K (Thr³⁸⁹), CDK4, p-Vimentin (Ser⁵⁶), filamin A or HMGCOA reductase. C Same as in (B) but for Set-2 patients (N = 101). D pCR rates of patients from Set-2 with combined elevated levels of CDK4 and filamin A compared to patients with low CDK4 and filamin A levels. Proportions were compared with a two-sided Xi-square test. P values are adjusted (Bonferroni). Error bars: standard error of the proportion. Source data are provided as a Source data file.