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. 2022 Dec 7;13(12):1028. doi: 10.1038/s41419-022-05472-7

Fig. 3. ETS1-overexpressed ovarian cancer cells secrete larger-sized exosomes with higher laminin levels.

Fig. 3

A Concentration and size distribution of exosomes derived from ovarian cancer cells transfected with lentivirus LV-ETS1 and LV-GFP (LV-ETS1 Exos and LV-GFP Exos) calculated by nanoparticle tracking analysis (NTA). B Average diameter of LV-ETS1 Exos and LV-GFP Exos. C, D Heatmap diagrams of upregulated protein between LV-ETS1 Exos and LV-GFP Exos derived from HO-8910 (C) and A2780 cells (D). Protein expression data were obtained using Label-free. E Venn diagram showing eight proteins that were upregulated in both cell lines LV-ETS1 Exos. F Western blotting showing LAMA5, LAMB1 and LAMC1 protein expression in ovarian cancer cells transfected with lentivirus LV-ETS1 and LV-GFP. G Western blotting showing LAMA5, LAMB1 and LAMC1 protein expression in LV-ETS1 Exos and LV-GFP Exos derived from HO-8910 and A2780 cells. Data are shown as mean ± SD. **P < 0.01.