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. 2022 Dec 7;13(12):1028. doi: 10.1038/s41419-022-05472-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Ex vivo bioluminescence analysis showing uptake of ovarian cancer exosomes by abdominal organs. B, C Flow cytometry analysis (B) and fluorescence microscope observation (C) showing uptake of PKH67-labeled LV-ETS1 Exos and LV-GFP Exos by omental macrophages. Scale bars: 20 μm at ×200 magnification. D Immunofluorescence analysis showing PKH26-labeled LV-ETS1 Exos and LV-GFP Exos (red), F4/80 (green), and DAPI (blue) staining in nude mice omentum. Scale bars: 10 μm at ×630 magnification. E Immunofluorescence analysis showing PKH26-labeled LV-ETS1 Exos and LV-GFP Exos (red), integrin αvβ5 (green) and DAPI (blue) staining in nude mice omentum. Scale bars: 10 μm at ×630 magnification. F Immunofluorescence analysis showing F4/80 (green), integrin αvβ5 (red) and DAPI (blue) staining in nude mice omentum. Scale bars: 10 μm at ×630 magnification. G Immunofluorescence analysis showed LAMA5, LAMB1 and LAMC1 (red) colocalized with integrin αvβ5 (green) in nude mice omentum. Scale bars: 10 μm at ×630 magnification. H, I Co-IP analysis showed LAMA5, LAMB1 and LAMC1 could interact with integrin αv (H) and integrin β5 (I) protein in RAW 264.7 cells. Data are shown as mean ± SD. **P < 0.01, ns non-significant.