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. 2022 Oct 4;66(1):190–200. doi: 10.1007/s00125-022-05793-4

Table 2.

Effects of liver fat on metabolic traits and of metabolic traits on intrapancreatic fat

Trait Standard coefficient SE p value
Liver fat and metabolic traits
 Effect of liver fat on HbA1c 0.016 0.013 0.172
 Effect of liver fat on fasting plasma glucose 0.028 0.011 0.008
 Effect of liver fat on fasting insulin 0.083 0.051 0.105
 Effect of liver fat on total cholesterol 0.073 0.070 0.297
 Effect of liver fat on HDL-cholesterol −0.100 0.253 <0.001
 Effect of liver fat on LDL-cholesterol 0.038 0.060 0.527
 Effect of liver fat on triacylglycerol 0.175 0.039 <0.001
 Effect of liver fat on ALT 0.163 0.055 0.004
 Effect of liver fat on AST 0.098 0.040 0.015
 Effect of liver fat on ALP 0.108 0.032 0.001
 Effect of liver fat on GGT 0.176 0.069 0.019
 Effect of liver fat on total amylin 0.072 0.063 0.257
 Effect of liver fat on C-peptide 0.132 0.103 0.204
 Effect of liver fat on total GLP-1 −0.050 0.076 0.513
 Effect of liver fat on GIP 0.009 0.089 0.920
 Effect of liver fat on glucagon 0.050 0.058 0.394
Metabolic traits and intrapancreatic fat
 Effect of HbA1c on intrapancreatic fat −0.369 0.504 0.465
 Effect of fasting plasma glucose on intrapancreatic fat 1.142 0.565 0.044
 Effect of fasting insulin on intrapancreatic fat 0.243 0.137 0.077
 Effect of total cholesterol on intrapancreatic fat 0.120 0.088 0.172
 Effect of HDL-cholesterol on intrapancreatic fat −0.832 0.238 0.001
 Effect of LDL-cholesterol on intrapancreatic fat 0.230 0.106 0.031
 Effect of triacylglycerol on intrapancreatic fat 0.614 0.205 0.003
 Effect of ALT on intrapancreatic fat 0.270 0.203 0.187
 Effect of AST on intrapancreatic fat 0.048 0.282 0.866
 Effect of ALP on intrapancreatic fat −0.025 0.349 0.943
 Effect of GGT on intrapancreatic fat 0.209 0.161 0.057
 Effect of total amylin on intrapancreatic fat 0.113 0.141 0.422
 Effect of C-peptide on intrapancreatic fat 0.114 0.087 0.194
 Effect of total GLP-1 on intrapancreatic fat 0.244 0.124 0.050
 Effect of GIP on intrapancreatic fat 0.338 0.106 0.002
 Effect of glucagon on intrapancreatic fat 0.251 0.152 0.099

Data on liver fat, HbA1c, fasting plasma glucose, fasting insulin, total amylin, C-peptide, total GLP-1, GIP, glucagon, ALT, AST, ALP, GGT and triacylglycerol were log-transformed

Single-mediator model with single-level data was used to investigate mediation. All mediation analyses were adjusted for age, sex, ethnicity and BMI

ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyl transpeptidase