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. 2022 Nov 24;13:1050690. doi: 10.3389/fphys.2022.1050690

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Copyright © 2022 Xu, Fan, Wang and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dysfunctional cell-cell communication in thin endometrium. Heatmap depicting differential incoming (A) and outgoing (B) signaling patterns in each cluster. Representative networks for enhanced (C,D) and reduced (E,F) signaling pathways. Left, circle plot showing the signals in cell-cell interactions between normal and thin endometrium; right, the expression level of ligand-receptor genes in individual signals. (G) Bar graph demonstrating the relative information flow of each signaling pathway between normal and thin endometrial tissues.