Table 3.
Within-pair association of BDI-II total score (per 10 units higher score) with DNAm age acceleration (in years) at the baseline and at the follow-up visit, using within-twin effect models.
| Visit | DNAm Age Acceleration (years) |
Model 1 Baseline N=260 Follow-up N=154 |
Model 2 Baseline N=260 Follow-up N=152 |
Model 3 Baseline N=246 Follow-up N=144 |
Model 4 Baseline N=246 Follow-up N=144 |
||||
|---|---|---|---|---|---|---|---|---|---|
| Estimate (95% CI) |
P | Estimate (95% CI) |
P | Estimate (95% CI) |
P | Estimate (95% CI) |
P | ||
| Baseline | HorvathAA | 0.15 (−0.47, 0.77) |
0.632 | 0.11 (−0.52, 0.73) |
0.739 | 0.076 (−0.56, 0.71) |
0.817 | −0.049 (−0.70, 0.61) |
0.885 |
| IEAA | 0.070 (−0.53, 0.67) |
0.818 | 0.020 (−0.58, 0.62) |
0.948 | −0.052 (−0.67, 0.57) |
0.870 | −0.16 (−0.80, 0.47) |
0.613 | |
| HannumAA |
0.91
(0.36, 1.47) |
0.002 |
0.88
(0.32, 1.44) |
0.003 |
0.81
(0.23, 1.40) |
0.008 |
0.73
(0.13, 1.33) |
0.019 | |
| EEAA |
1.11
(0.44, 1.78) |
0.002 |
1.07
(0.40, 1.75) |
0.002 |
1.05
(0.35, 1.75) |
0.004 |
0.94
(0.22, 1.66) |
0.012 | |
| GrimAA | 0.56 (−0.12, 1.24) |
0.110 | 0.40 (−0.24, 1.05) |
0.225 | 0.40 (−0.26, 1.06) |
0.237 | 0.45 (−0.23, 1.14) |
0.198 | |
| PhenoAA |
0.75
(0.029, 1.47) |
0.044 | 0.63 (−0.10, 1.35) |
0.094 | 0.61 (−0.14, 1.37) |
0.115 | 0.64 (−0.14, 1.42) |
0.112 | |
| Follow-up | HorvathAA | 0.11 (−0.81, 1.03) |
0.818 | 0.11 (−0.82, 1.03) |
0.823 | 0.016 (−0.94, 0.97) |
0.975 | 0.013 (−0.95, 0.97) |
0.979 |
| IEAA | 0.34 (−0.57, 1.25) |
0.468 | 0.34 (−0.57, 1.25) |
0.465 | 0.29 (−0.65, 1.23) |
0.547 | 0.28 (−0.67, 1.23) |
0.565 | |
| HannumAA | 0.26 (−0.44, 0.96) |
0.467 | 0.27 (−0.43, 0.98) |
0.447 | 0.27 (−0.47, 1.00) |
0.481 | 0.28 (−0.46, 1.03) |
0.455 | |
| EEAA | 0.20 (−0.69, 1.08) |
0.664 | 0.22 (−0.67, 1.10) |
0.629 | 0.15 (−0.78, 1.07) |
0.757 | 0.16 (−0.76, 1.09) |
0.729 | |
| GrimAA |
1.20
(0.18, 2.22) |
0.023 |
1.01
(0.048, 1.97) |
0.043 |
1.00
(0.024, 1.98) |
0.049 | 0.99 (−0.011, 1.99) |
0.052 | |
| PhenoAA |
1.48
(0.37, 2.58) |
0.011 |
1.44
(0.34, 2.54) |
0.012 |
1.33
(0.19, 2.47) |
0.025 |
1.32
(0.18, 2.47) |
0.027 | |
Abbreviation: CI, confidence interval.
Model 1: adjusted for zygosity;
Model 2: Model 1 + current smoking, coronary heart disease history;
Model 3: Model 2 + BMI, number of alcoholic drinks per week, Baecke score of physical activity;
Model 4: Model 3 + PTSD.