Table 2.
Results of Regression Analyses Predicting RNA Age Residuals in Three Brain Regions
| Variable | dlPFC | vmPFC | Motor | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| B | SE | β | P | P-adj | B | SE | β | P | P-adj | B | SE | β | P | P-adj | |
| qSV1 | .03 | .04 | .08 | .46 | .02 | .03 | .06 | .61 | .03 | .03 | .11 | .32 | |||
| qSV2 | −.04 | .06 | −.07 | .56 | −.04 | .06 | −.08 | .49 | .04 | .06 | .09 | .45 | |||
| qSV3 | −.14 | .11 | −.15 | .21 | .004 | .10 | .01 | .97 | −.04 | .10 | −.04 | .71 | |||
| Sex | .81 | 1.25 | .08 | .52 | −1.56 | 1.16 | −.15 | .18 | −.91 | 1.08 | −.10 | .40 | |||
| Cigarette-use | .37 | 1.33 | .03 | .78 | −1.05 | 1.27 | −.10 | .41 | −.10 | 1.15 | −.01 | .93 | |||
| AUD | −1.50 | 1.35 | −.13 | .27 | −1.03 | 1.25 | −.10 | .41 | .12 | 1.16 | .01 | .92 | |||
| PTSD/MDD | .38 | 1.62 | .03 | .82 | .82 | 4.66 | 1.58 | .39 | .004 | .012 | 1.49 | 1.39 | .14 | .29 | .435 |
Note. qSV = quality surrogate variable; AUD = alcohol-use disorder; PTSD/MDD = posttraumatic stress disorder or major depressive disorder; dlPFC = dorsolateral prefrontal cortex; vmPFC = ventromedial prefrontal cortex; B = unstandardized coefficient; SE = standard error; β = standardized coefficient; p-adj= FDR adjusted p-value across three brain regions.