Table 2.
Mean (SD) levels of inflammation-related biomarkers by individual and combined physical activity and BMI groups in colorectal cancer patients enrolled in the ColoCare Study at the National Center for Tumor Diseases (NCT) and University of Heidelberg (HD), Heidelberg in Germany and the Huntsman Cancer Institute (HCI), Salt Lake City, Utah and the Fred Hutchinson Cancer Center (FHCC), Seattle, Washington in the USA between June 2007 and July 2019.
| Biomarker | BMI groups | ||
|---|---|---|---|
| Normal weight (≥18.5 and <25 kg/m2) N=207 |
Overweight (≥25 and <30 kg/m2) N=218 |
Obese (≥30 kg/m2) N=154 |
|
| CRP (mg/L) | 21.1 (41.6) | 14.5 (32.0) | 18.3 (33.3) |
| SAA (mg/L) | 35.3 (66.8) | 27.0 (60.2) | 39.9 (81.4) |
| IL-6 (pg/ml) | 16.3 (77.6) | 16.6 (60.7) | 12.5 (44.2) |
| IL-8 (pg/ml) | 43.5 (99.2) | 58.3 (186) | 40.7 (115) |
| TNF-α (pg/ml) | 2.87 (1.25) | 3.01 (1.86) | 3.20 (1.24) |
| Physical activity groups | ||
|---|---|---|
| Inactive (<8.75 MET-hrs/wk) N=29 |
Active (≥8.75 MET-hrs/wk) N=40 |
|
| CRP (mg/L) | 17.2 (5.9) | 18.2 (6.0) |
| SAA (mg/L) | 28.7 (56.4) | 36.7 (76.2) |
| IL-6 (pg/ml) | 12.4 (49.1) | 17.6 (72.2) |
| IL-8 (pg/ml) | 44.2 (116) | 51.7 (158) |
| TNF-α (pg/ml) | 2.95 (1.91) | 3.04 (1.14) |
| Physical activity/BMI-based groups | ||||
|---|---|---|---|---|
| Normal weight (≥18.5 and <25 kg/m2) |
Overweight/obese (≥0 kg/m2) |
|||
| Active N=102 |
Inactive N=105 |
Active N=17 |
Inactive N=25 |
|
| CRP (mg/L) | 19.1 (40.1) | 32.2 (4.) | 15.8 (2.4) | 16.3 (2.6) |
| SAA (mg/L) | 30.7 (56.9) | 40.1 (75.7) | 27.2 (56.2) | 35.3 (76.6) |
| IL-6 (pg/ml) | 0.39 (28.6) | 22.7 (104) | 14.5 (59) | 15.2 (51.7) |
| IL-8 (pg/ml) | 47.2 (10) | 40.1 (58.0) | 42.1 (107) | 57.3 (189) |
| TNF-α (pg/ml) | 2.85 (1.26) | 2.88 (1.24) | 3.02 (2.26) | 3.12 (1.08) |
Abbreviations: SD: standard deviation, CRP:C reactive protein, SAA: serum amyloid A, IL-6/-8:interleukin-6/-8, TNF-α: tumor necrosis factor alpha, kg: kilogram, hrs/wk: hours per week, mg/L: milligram per liter, pg/L: picogram per liter