Table 3.

Multiple linear regression model testing associations between individual physical activity and BMI groups with inflammation-related biomarkers in colorectal cancer patients enrolled in the ColoCare Study at the National Center for Tumor Diseases (NCT) and University of Heidelberg (HD), Heidelberg in Germany and the Huntsman Cancer Institute (HCI), Salt Lake City, Utah and the Fred Hutchinson Cancer Center (FHCC), Seattle, Washington in the USA between June 2007 and July 2019.

	RD (%)	β ± SE	p-value
Physical activity groups
Inactive (<8.75-MET-hrs/wk) vs. active (≥8.75-MET-hrs/wk)
CRP (mg/L)	+39	0.33±0.23	0.15
SAA (mg/L)	+26	0.23±0.22	0.30
IL-6 (pg/ml)	+36	0.31±0.19	0.10
IL-8 (pg/ml)	+8	0.08±0.13	0.51
TNF-α (pg/ml)	+6	0.06±0.05	0.21
BMI groups
Overweight vs. normal weight
CRP (mg/L)	−4	−0.04±0.26	0.89
SAA (mg/L)	−27	−0.32±0.25	0.20
IL-6 (pg/ml)	−10	−0.10±0.22	0.66
IL-8 (pg/ml)	−1	−0.01±0.15	0.94
TNF-α (pg/ml)	+2	0.03±0.06	0.59
Obese vs. normal weight
CRP (mg/L)	+88	0.63±0.29	0.03
SAA (mg/L)	+15	0.14±0.27	0.20
IL-6 (pg/ml)	+25	0.22±0.25	0.38
IL-8 (pg/ml)	0	0.002±0.17	0.99
TNF-α (pg/ml)	+17	0.16±0.07	0.02

Note: Biomarker levels were log-2 transformed. Analyses were adjusted for age, sex, stage at diagnosis, and neoadjuvant treatment; Abbreviations: RD: percentage relative difference (exp(β-coefficient)-1)*100); β:beta coefficient, SE: standard error, p: p-value, CRP:C reactive protein, SAA: serum amyloid A, IL-6/-8:interleukin-6/-8, TNF-α: tumor necrosis factor alpha; Bold numbers indicate statistical significance