Table 1.

Overview of characteristics of the included studies (n = 9)

Author and year	Design	No. of patients	Treatment-arms (no. of implants)	Healing period/follow-up
Aimetti et al. 2018 [21]	RCT	30	i.DBBM + collagen and membrane (n = 15) ii.Spont. healing (n = 15)	12 months
Ben Amara et al. 2021 [23]	RCT	34	i.DBBM + collagen and membrane (n = 18) ii.Spont. healing (n = 16)	6 months
Iorio-Siciliano et al. 2017 [22]	RCT	20	i.DBBM and membrane (n = 10) ii.Spont. healing (n = 10)	6 months
Iorio-Siciliano et al. 2020 [16]	RCT	40	i.DBBM + collagen and membrane (n = 12) ii.DBBM and membrane (n = 13) iii.Spont. healing (n = 15)	6 months
Jonker et al. 2021 [18]	RCT	75	i.DBBM + collagen and collagen matrix (n = 25) ii.DBBM + collagen and CTG (n = 25) iii.Spont. healing (n = 25)	2 months
Jung et al. 2013 [17]	RCT	40	i.DBBM + collagen and membrane (n = 10) ii.Beta-TCP (n = 10) iii.DBBM + collagen and CTG (n = 10) iv.Spont. healing (n = 10)	6 months
Jung et al. 2018 [15]	RCT split-mouth	18	i.DBBM and membrane (n = 18) ii.Spont. healing (n = 18)	3 and 6 months
Machtei et al. 2019 [19]	RCT	33	i.DBBM (n = 11) ii.Alloplast (n = 11) iii.Spont. healing (n = 11)	4 months
Stumbras et al. 2021 [20]	RCT	40	i.DBBM and membrane (n = 10) ii.Allograft and membrane (n = 10) iii.PRGF (n = 10) iv.Spont. healing (n = 10)	3 months

DBBM, deproteinized bovine bone mineral; CTG, connective tissue graft; Beta-TCP, beta tricalcium phosphate, PRGF, platelet rich growth factors