TABLE 1.
Characteristics of included RCTs.
| Study | Interventions | Location | Year | Number | Age (mean ± SD) | Baseline (HAMD-17, mean ± SD/median, IQR) | Dosage (per day) | Follow-up (weeks) | Scales |
|---|---|---|---|---|---|---|---|---|---|
| Kanes | Brexanolone/Placebo | Multicenter | 2017 | 10/11 | 27.4 ± 5.3/28.8 ± 4.6 | 28.1 (27.0–30.0)/28.8 (26.0–32.0) | 30-60 ug/h | 30d | HAMD-17/MADRS |
| Meltzer-Brody-1 | Brexanolone/Placebo | USA | 2018 | 92/46 | 27.3 ± 6.1/27.8 ± 6.0 27/27.0 ± 6.0 | 29.1 ± 2.7/28.4 ± 2.5/28.6 ± 2.5 | 30-90 ug/h | 30d | HAMD-17/MADRS |
| Meltzer-Brody-2 | Brexanolone/Placebo | USA | 2018 | 54/54 | 28.4 ± 6.1/27.4 ± 5.9 | 22.6 ± 1.6/22.7 ± 1.6 | 30-90 ug/h | 30d | HAMD-17/MADRS |
| Appleby | Fluoxetine/Placebo | UK | 1997 | 43/44 | 26.1/24.5 | 14.2 (13.0-15.5) 13.9 (12.5-15.4) | NA | 12 | HAMD-17/EPDS |
| O’Hara-Iowa | Sertraline/Placebo | USA | 2010 | 23/20 | 28.7 ± 5.9/ 28.1 ± 5.4 | 21.5 ± 4.5/20.2 ± 4.4 | 25-200 mg | 12 | HAMD-17 |
| O’Hara-WIH | Sertraline/Placebo | USA | 2010 | 33/33 | 27.8 ± 5.5/ 26.8 ± 4.9 | 22.1 ± 5.0/23.2 ± 4.5 | 25-200 mg | 12 | HAMD-17 |
| Kashani | Saffron/Fluoxetine | Iran | 2017 | 32/32 | 29.21 ± 7.69 | 16.53 ± 1.48 | NA | 6 | HAMD-17 |
| 32.09 ± 4.99 | 16.65 ± 1.12 | ||||||||
| Hantsoo | Sertraline/Placebo | USA | 2013 | 17/19 | 29.6 ± 4.0/31.7 ± 3.7 | 20.6 ± 2.8/23.2 ± 3.9 | 50-200 mg | 6 | HAMD-17/EPDS |
| Wisner | Sertraline/Nortriptyline | USA | 2006 | 55/54 | NA | NA | 25-200 mg/10-150 mg | 8 | HAMD-17 |
| Yonkers | Paroxetine/Placebo | USA | 2008 | 35/35 | 26.1 ± 6.5/25.9 ± 6.5 | 23.6 ± 4.7/24.7 ± 5.0 | 10-40 mg | 8 | HAMD-17 |
| Li | Estradiol/Placebo | USA | 2020 | 6/6 | 30.5 ± 6.2/32.7 ± 5.5 | 18.2 ± 7.3/18.3 ± 3.4 | 5 mg | 6 | HAMD-17/EPDS |
| Bloch | Sertraline/Placebo | Israel | 2012 | 20/20 | NA | 18.40 ± 4.83 16.05 ± 4.84 | 25-100 mg | 12 | EPDS/MADRS |
| Deligiannidis | Zuranolone/Placebo | USA | 2021 | 76/74 | 29.3 ± 5.4/27.4 ± 5.3 | 28.4 ± 2/28.8 ± 2 | 30 mg | 45d | HAMD-17/MADRS |
Abbreviations: EPDS, Edinburgh Postnatal Depression Scale; HAMD-17, 17-item Hamilton Rating Scale for Depression score; IQR, interquartile range; MADRS, Montgomery-Åsberg Depression Rating Scale; NA, not available; SD, standard deviation.