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. 2022 Nov 24;13:1052091. doi: 10.3389/fphar.2022.1052091

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Copyright © 2022 Roefs, Heusermann, Brans, Snijders Blok, Lei, Vader and Sluijter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Long-term EV distribution in the mouse after intramyocardial injection. (A) Schematic overview of intramyocardial (IM) EV administration in the left ventricle wall and near-infrared (NIRF) imaging up to 5 days after intramyocardial injection. (B,C) Representative NIRF images taken from (B) the eppendorf containing labeled EVs, (C) the living animal at various time points after EV administration and (D) of individual organs collected after 5 days follow-up. Uncut images are included in Supplementary Figure S11. (E) Quantification of fluorescence (800nm) per ng protein in organ lysates as compared to organ background. Data of two mice are shown and are displayed as mean ± SD.