Table 2.

SARS-CoV- 2 VOCs inhibition (EC₅₀) for the three lead NPs in Calu-3 cells.

Name	Delta (EC₅₀)		BA.1 (EC₅₀)		BA.2 (EC₅₀)		BA.5 (EC₅₀)
Name	Nuc^a	dsRNA	Nuc^a	dsRNA	Nuc^a	dsRNA	Nuc^a	dsRNA
holyrine A	600 nM	1.0 μM	1.7 μM	1.6 μM	44 nM	394 nM	80 nM	120 nM
alotaketal C	4.9 μM	3.9 μM	700 nM	400 nM	700 nM	700 nM	300 nM	700 nM
bafilomycin D	2.0 nM	50 nM	13.4 nM	67.3 nM	4.6 nM	22 nM	43.9 nM	38.6 nM

Nuc = Nucleocapsid.