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. 2022 Dec 8;131:106316. doi: 10.1016/j.bioorg.2022.106316

Table 2.

Inhibitory activities of saponins BA-1-BA-16 against infection of 293 T-ACE2 cells by pSARS-CoV-2.

Compound R EC50a (μM) CC50b(μM) SIc
BA-1 CH3 4.64 ± 0.52 40.88 ± 0.25 8.81
BA-2 OH ＞20.00 NT NT
BA-3 Et 3.70 ± 0.72 36.12 ± 1.05 9.76
BA-4 n-propyl 3.12 ± 0.40 39.13 ± 0.73 12.54
BA-5 graphic file with name fx1_lrg.gif 6.42 ± 0.20 76.49 ± 1.23 11.91
BA-6 graphic file with name fx2_lrg.gif 5.37 ± 0.37 24.36 ± 0.33 4.54
BA-7 graphic file with name fx3_lrg.gif 5.54 ± 0.81 16.39 ± 0.19 2.96
BA-8 graphic file with name fx4_lrg.gif 6.05 ± 0.38 47.25 ± 0.63 7.81
BA-9 graphic file with name fx5_lrg.gif ＞20.00 NT NT
BA-10 graphic file with name fx6_lrg.gif 7.67 ± 0.31 51.81 ± 1.35 6.75
BA-11 graphic file with name fx7_lrg.gif 9.03 ± 0.56 46.12 ± 0.31 5.11
BA-12 graphic file with name fx8_lrg.gif ＞20.00 NT NT
BA-13 graphic file with name fx9_lrg.gif 8.61 ± 0.47 36.21 ± 0.75 4.21
BA-14 graphic file with name fx10_lrg.gif 8.23 ± 0.55 84.62 ± 0.76 10.28
BA-15 graphic file with name fx11_lrg.gif 15.90 ± 0.82 75.52 ± 1.63 4.75
BA-16 graphic file with name fx12_lrg.gif 3.13 ± 0.42 12.79 ± 0.25 4.09
Sal-C / 4.06 ± 0.51 >100.00 >24.63
a

The samples were examined in 293 T-ACE2 cells in triplicate. 293 T-ACE2 cells were incubated with test compounds and pSARS-CoV-2, and the concentration of test compound resulting in 50 % cell protection was reported as the EC50. Values are the mean of three experiments, presented as the mean ± standard deviation (SD). b50% cellular cytotoxicity concentration (CC50). cSI: selectivity index as CC50/EC50.