. 2022 Dec 3;17:5915–5931. doi: 10.2147/IJN.S382968

Table 2.

Fitting Results for in vitro BH Release from MMt-BH-HA/CS-ED NPs (n = 3)

Formulations	Models	Equation	R²
BH solution	Zero order	Q=26.1006t+35.2629	0.7684
	First order	Q=100.1165(1-e^−1.4750t)	0.9991
	Higuchi	Q=65.6805t^1/2+3.6894	0.9632
BH-HA/CS-ED NPs	Zero order	Q=5.1907t+50.5838	0.4592
	First order	Q=94.3996(1-e^−1.0038t)	0.9983
	Higuchi	Q=23.9044t^1/2+ 29.3399	0.7019
	Ritger-Pappas	Q=59.5571t^0.2992	0.8523
MMt-BH-HA/CS-ED NPs	Zero order	Q=43.9046t+4.7431	0.4878
	First order	Q=83.7642 (1-e^−0.9699t)	0.9988
	Higuchi	Q=21.6207t^1/2+21.9146	0.7274
	Ritger-Pappas	Q=52.0017t^0.2372	0.8671