TABLE 2.

Association between severe headache or migraine and CVD in the database from NHANES 1999-2004 (weighted).

	Unweighted number of total participants	Unweighted number of CVD participants	Model 1 OR (95% CI)	Model 2 OR (95% CI)	Model 3 OR (95% CI)
Without severe headache or migraine	4602	636	1 (Ref).	1 (Ref).	1 (Ref).
With severe headache or migraine	1090	121	1.82 (1.27-2.61)	1.87 (1.22-2.88)	2.77 (1.56-4.90)
P-value			0.002	0.006	0.001

Model 1 was adjusted for age, sex, race, and education. Model 2 was adjusted for Model 1 + poverty, physical activity, smoking status, alcohol intake, BMI, waist, DM, hypertension, and hyperlipidemia. Model 3 was adjusted for Model 2 + eGFR, triglyceride, total cholesterol, LDL-C, HDL-C.

NHANES, National Health and Nutrition Examination Survey; CVD, cardiovascular disease; BMI, body mass index; DM, diabetes mellitus; LDL-C, low-density lipoprotein cholesterol; HDL-C, high density leptin cholesterol; eGFR, estimated glomerular filtration rate; OR, odds ratio; CI, confidence interval.