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. 2022 Nov 24;9:1023438. doi: 10.3389/fcvm.2022.1023438

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Copyright © 2022 Tang, Kuang, Shan, Shi, Li, Qiu and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Edgeworthia gardneri (Wall.) Meisn attenuates atherogenesis in mice by inhibiting macrophage foam cell formation via decreasing CD36-mediated ox-LDL uptake. EEEG inhibited macrophage-derived foam cell formation induced by oxidized low-density lipoprotein (ox-LDL) by reducing CD36-mediated lipoprotein uptake. Furthermore, EEEG treatment significantly downregulated mRNA expression of hepatic Srb1 and intestinal Npc1l1 and increased expression of hepatic Cyp7a1, which may promote the reverse cholesterol transport and decrease the serum levels of cholesterol. In conclusion, EEEG may play a role in attenuating atherosclerotic plaque formation by reducing macrophage foam cell formation.