TABLE 1.

Selected “best model” and results of the Anova Type III tests of the predictor variables on log-transformed MTR, ADC and T2 data of male (m) (top) and female (f) (bottom) mice.

	Param.	Model/Effects	A	T	D	AT	DA	TD	DAT
m	MTR	ATrsD.AT.DT.DA	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001	n.i.
	ADC	ATrsD.AT	p < 0.001	p < 0.001	p < 0.001	p < 0.005	n.i.	n.i.	n.i.
	T2	ATrsD.AT.DT.DA	p < 0.001	n.s	n.s	p < 0.001	p < 0.001	n.s	n.i.
f	MTR	A	p < 0.001	n.i.	n.i.	n.i.	n.i.	n.i.	n.i.
	ADC	ATrsD.AT	p < 0.001	n.s.	n.s.	p < 0.001	n.i.	n.i.	n.i.
	T2	ATrsD.AT.DA	p < 0.001	n.s	n.s	p < 0.001	p < 0.05	n.s.	n.i.

Small p-values indicate significant effects of the fixed effects (A: Area; T: Time; D: Diet; AT: Area*time interaction; TD: Time*diet interaction; DA: Diet*area interaction; DAT; Diet*time*area interaction) on the corresponding MRI parameter. The “best model” used is specified in the third column (A: Area model; ATrsD.AT.DT.DA: Area, Time random slope, diet, area*time, diet*time, diet*area model, ATrsD.AT: Area, Time random slope, diet, area*time model).