AAV8-Lhcgr restarts sexual development in pubertal Lhcgr−/− mice
(A and B) Representative photographs of the external (A) and internal genitalia (B) of Lhcgr+/+ mice, Lhcgr+/− mice, and Lhcgr−/− mice injected with PBS or AAV8-Lhcgr (n = 5). Arrows (A) and arrowheads (B) indicate the testes. Scale bar: 1 cm.
(C–J) Ano-genital distance (C), penile length (D), testis weight (E), epididymis weight (F), seminal vesicle weight (G), prostate weight (H), vas deferens weight (I), and vas deferens length (J) of Lhcgr+/+ mice, Lhcgr+/− mice, and Lhcgr−/− mice injected with PBS or AAV8-Lhcgr (n = 5). Data are represented by boxplots, and whiskers show the minimum to maximum values. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ns, not significant.