REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit anti-PDGFRα	Abcam	Cat# ab203491; RRID: AB_2892065
Rabbit anti-Nestin	GeneTex	Cat# GTX133111; RRID: AB_2886832
Rabbit anti-DDX4	CST	Cat# 8761; RRID: AB_2797658
Rabbit anti-SOX9	Millipore	Cat# AB5535; RRID: AB_2239761
Rabbit anti-CYP17A1	CST	Cat# 94004; RRID: AB_2800219
Rabbit anti-α-SMA	Abcam	Cat# ab5694; RRID: AB_2223021
Rabbit anti-AIF1	GeneTex	Cat# GTX100042; RRID: AB_1240434
Mouse anti-LHCGR	Novus	Cat# NBP2-54479; RRID: NA
Mouse anti-TNP2	Santa Cruz	Cat# SC-393843; RRID: NA
Chicken anti-mCherry	Abcam	Cat# ab205402; RRID: AB_2722769
Rat Anti-Mouse CD4	BD	Cat# 557667; RRID: AB_396779
Rat Anti-Mouse CD8	BD	Cat# 557668; RRID: AB_396780
Goat Anti-rabbit Alexa Fluor 488	Invitrogen	Cat# A11037; RRID: AB_2534095
Goat Anti-rabbit Alexa Fluor 647	Invitrogen	Cat# A32733; RRID: AB_2633282
Goat Anti-mouse Alexa Fluor 647	Invitrogen	Cat# A32728; RRID: AB_2633277
Goat Anti-chicken Alexa Fluor 555	Invitrogen	Cat# A32932; RRID: AB_2762844
Bacterial and virus strains
AAV-Lhcgr	Vigene Bioscience	N/A
AAV-mCherry	Vigene Bioscience	N/A
Chemicals, peptides, and recombinant proteins
Avertin	Sigma-Aldrich	Cat# T48402
Triton X-100	Sigma-Aldrich	Cat# X100
Chorionic gonadotropin human (hCG)	Sigma-Aldrich	Cat# 1297001
Mineral oil	Sigma-Aldrich	Cat# M5310
Bouin’s solution	Sigma-Aldrich	Cat# HT10132
DAPI	Invitrogen	Cat# P36966
PFA	Phygene	Cat# PH0427
Bovine Serum Albumin	Sigma-Aldrich	Cat# A7030
TYH Medium	This paper	N/A
KSOM Medium	This paper	N/A
Tissue-Tek® O.C.T. Compound	Sakura	Cat# 4583
Peanut agglutinin, PNA	Sigma	Cat# L7381; RRID: NA
Critical commercial assays
RNeasy Kits	QIAGEN	Cat# 74116
Recombinant NovoScript 1st Strand cDNA Synthesis Kit	Novoprotein	Cat# E041
LightCycler® 480 SYBR Green I Master	Roche	Cat# 04887352001
TIANamp Genomic DNA kit	TIANGEN	Cat# 4992254
Deposited data
Expression matrix	This paper	Database: https://ngdc.cncb.ac.cn/omix/ Project number: OMIX001301
Experimental models: Organisms/strains
Mouse: Lhcgr+/− breeding pairs	Z.L. et al.18	N/A
Monkey: Cynomolgus monkey	Guangdong Blooming-spring Biological Technology Development Co., Ltd.	N/A
Oligonucleotides
Primers used for quantitative RT-PCR, genotyping and integration assay	This Paper	Table S2
Software and algorithms
SPSS 20.0	IBM	https://www.ibm.com/uk-en/analytics/spss-statistics-software
R v. 4.0.2		https://www.r-project.org
pheatmap v. 1.0.12	Raivo Kolde	https://cran.r-project.org/web/packages/pheatmap/index.html
biomaRt v. 2.46.3	Durinck Steffen et al.42	https://www.bioconductor.org/packages/release/bioc/html/biomaRt.html
clusterProfiler v. 4.0.5	T. Wu et al.43	https://www.bioconductor.org/packages/release/bioc/html/clusterProfiler.html
ggplot2 v. 3.3.5	Hadley Wickham et al.	https://cran.r-project.org/web/packages/ggplot2/index.html