Figure 2.

FLT3 genetic alterations occur most frequently in acute myeloid leukemia (AML) patients and are associated with worse prognoses. A. Bar plot of FLT3 genetic alterations across different cancer types (upper panel). The lower panel shows individual types of FLT3 genetic alterations in 31% of AML cases in TCGA database. B. Kaplan-Meir plot of survival differences between AML patients with FLT3 alterations vs. patients with wild-type FLT3. C. Three-dimensional view of FLT3 showing specific mutations in AML patients. D. Frequencies of the co-occurrence of FLT3 genetic alteration with other genes in AML patients in TCGA.