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. 2022 Nov 15;12(11):5140–5159.

Figure 3.

Figure 3

FLT3 mutations are associated with dysfunctional T-cell phenotypes, high risk, and shorter survival of acute myeloid leukemia (AML) patients. A. Summary plot of immune responses of FLT3 mutant-bearing AML patients. B. Scatterplot of the correlation between FLT3 mutations and levels of active cytotoxic T cells. C. Plot of dysfunctional T-cell phenotypes showing that mutant FLT3 expression induced a state of dysfunctional T cells. D. Kaplan-Meir plot of differences in immune responses between FLT3 mutant-bearing vs. FLT3-wild-type (WT)-bearing AML patients.