Figure 6.

Overview of Lwkn-019 (N19), a novel anti-leukemia small molecule. A. Overview of the synthesis of Lwkn019 (10-chloro-6-(4-(3-(piperidin-4-yl)propyl)piperidin-1-yl)-12H-thiochromeno[2,3-c]quinolin-12-one) [42]. B. Chemical structure of Lwk-n019. C. Binding conformation of N19 with FLT3. The ring and chain groups of Lwkn-09 respectively formed three and two hydrogen bonds with FLT3 residues. Hydrogen bonds between residues and Lwkn-09 are represented as light-green dashes. The ring group also produced stable van der Waals interactions with the binding target.