Table 2.
Univariate Cox regression analyses of clinical pathological variables against PFS and OS in the TCGA cohort with 33 KRAS-mutated MSS CRC patients
| Characteristics | Number of patients | PFS | OS | ||||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| Number of events | HR, 95% CI | P-value | Number of events | HR, 95% CI | P-value | ||
| Pathology subtype | |||||||
| COAD | 24 | 17 | ref | 14 | ref | ||
| READ | 9 | 4 | 0.45 [0.15-1.35] | 0.155 | 1 | 0.14 [0.02-1.07] | 0.058 |
| Molecular subtype | |||||||
| CIN | 28 | 18 | ref | 13 | ref | ||
| GS | 2 | 1 | 0.72 [0.1-5.42] | 0.748 | 1 | 1.42 [0.18-11.05] | 0.738 |
| Sex | |||||||
| Female | 16 | 8 | ref | 6 | ref | ||
| Male | 17 | 13 | 0.87 [0.36-2.11] | 0.754 | 9 | 0.99 [0.35-2.8] | 0.985 |
| pN | |||||||
| N0 | 3 | 2 | ref | 2 | ref | ||
| N1 | 13 | 8 | 0.68 [0.14-3.24] | 0.627 | 5 | 0.34 [0.06-1.82] | 0.209 |
| N2 | 17 | 11 | 0.85 [0.19-3.86] | 0.829 | 8 | 0.52 [0.11-2.49] | 0.413 |
| pM | |||||||
| MX | 3 | 1 | ref | 0 | ref | ||
| M1 | 30 | 20 | 3.26 [0.44-24.39] | 0.250 | 15 | \ | |
| Age | 33 | 21 | 1.01 [0.97-1.05] | 0.647 | 15 | 1.09 [1.02-1.16] | 0.010 |
COAD: Colon Adenocarcinoma; READ: Rectum Adenocarcinoma; CIN: Chromosomal Instability; GS: Genomic Stable; MSS: Microsatellite Stable; CRC: Colorectal Cancer; TCGA: The Cancer Genome Atlas; PFS: Progression-Free Survival; OS: Overall Survival.