Table 1.
The significantly altered proteins involved in DNA damage or repair pathways
| A. Up-expressed protein in response to ATO/AZD | |||
|
| |||
| Gene name | Protein name | Gene name | Abundance Ratio (ATO/AZD)/Ctl. |
|
| |||
| HMOX1 | Heme oxygenase 1 | HMOX1 | 100 |
| SMARCA1 | Probable global transcription activator SNF2L1 | SMARCA1 | 100 |
| MT1E | Metallothionein-1E | MT1E | 100 |
| UBE2E3 | Ubiquitin-conjugating enzyme E2 E3 | UBE2E3 | 100 |
| RIT1 | GTP-binding protein Rit1 | RIT1 | 100 |
| PCSK9 | Proprotein convertase subtilisin/kexin type 9 | PCSK9 | 100 |
| PINX1 | PIN2/TERF1-interacting telomerase inhibitor 1 | PINX1 | 100 |
| CEBPD | CCAAT/enhancer-binding protein delta | CEBPD | 100 |
| TP73 | Tumor protein p73 | TP73 | 100 |
| PDK1 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial | PDK1 | 7.86 |
| VIM | Vimentin | VIM | 5.99 |
| AKR1C3 | Aldo-keto reductase family 1 member C3 | AKR1C3 | 5.72 |
| GDF15 | Growth/differentiation factor 15 | GDF15 | 5.16 |
| AKT3 | RAC-gamma serine/threonine-protein kinase | AKT3 | 4.75 |
| LCN2 | Neutrophil gelatinase-associated lipocalin | LCN2 | 4.30 |
| ANXA1 | Annexin A1 | ANXA1 | 4.11 |
| PDCD4 | Programmed cell death protein 4 | PDCD4 | 3.04 |
|
| |||
| B. Down-expressed protein in response to ATO/AZD | |||
|
| |||
| Gene name | Protein name | Gene name | Abundance Ratio (ATO/AZD)/Ctl. |
|
| |||
| AHNAK | Neuroblast differentiation-associated protein AHNAK | AHNAK | 0.40 |
| DNMT1 | DNA (cytosine-5)-methyltransferase 1 | DNMT1 | 0.40 |
| SNRNP200 | U5 small nuclear ribonucleoprotein 200 kDa helicase | SNRNP200 | 0.39 |
| RCC2 | Protein RCC2 | RCC2 | 0.36 |
| FANCI | Fanconi anemia group I protein | FANCI | 0.35 |
| CHD4 | Chromodomain-helicase-DNA-binding protein 4 | CHD4 | 0.35 |
| DHX9 | ATP-dependent RNA helicase A | DHX9 | 0.33 |
| DDX21 | Nucleolar RNA helicase 2 | DDX21 | 0.33 |
| RECQL | ATP-dependent DNA helicase Q1 | RECQL | 0.32 |
| ANT2 | ADP/ATP translocase 2 | ANT2 | 0.32 |
| TRRAP | Transformation/transcription domain-associated protein | TRRAP | 0.32 |
| EP300 | Histone acetyltransferase p300 | EP300 | 0.32 |
| MSH6 | DNA mismatch repair protein Msh6 | MSH6 | 0.31 |
| MCM5 | DNA replication licensing factor MCM5 | MCM5 | 0.28 |
| PRMT1 | Protein arginine N-methyltransferase 1 | PRMT1 | 0.28 |
| CEP131 | Centrosomal protein of 131 kDa | CEP131 | 0.27 |
| USP24 | Ubiquitin carboxyl-terminal hydrolase 24 | USP24 | 0.26 |
| PML | Protein PML | PML | 0.26 |
| NAT10 | RNA cytidine acetyltransferase | NAT10 | 0.25 |
| PLK1 | Serine/threonine-protein kinase PLK1 | PLK1 | 0.24 |
| CHD3 | Chromodomain-helicase-DNA-binding protein 3 | CHD3 | 0.22 |
| PKMYT1 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | PKMYT1 | 0.22 |
| SETDB1 | Histone-lysine N-methyltransferase SETDB1 | SETDB1 | 0.22 |
| DICER1 | Endoribonuclease Dicer | DICER1 | 0.21 |
| ERCC6 | DNA excision repair protein ERCC-6 | ERCC6 | 0.21 |
| HERC2 | E3 ubiquitin-protein ligase HERC2 | HERC2 | 0.21 |
| RRM2 | Ribonucleoside-diphosphate reductase subunit M2 | RRM2 | 0.20 |
| TSC2 | Tuberin | TSC2 | 0.20 |
| TMBIM6 | Bax inhibitor 1 | TMBIM6 | 0.20 |
| WDR18 | WD repeat-containing protein 18 | WDR18 | 0.18 |
| EP400 | E1A-binding protein p400 | EP400 | 0.18 |
| ATR | Serine/threonine-protein kinase ATR | ATR | 0.17 |
| SETX | Probable helicase senataxin | SETX | 0.15 |
| POLE | DNA polymerase epsilon catalytic subunit A | POLE | 0.12 |
| NSD2 | Histone-lysine N-methyltransferase NSD2 | NSD2 | 0.09 |
| SLC35F2 | Solute carrier family 35 member F2 | SLC35F2 | 0.09 |
| TXNL1 | Thioredoxin-like protein 1 | TXNL1 | 0.09 |
| APOBEC3F | DNA dC->dU-editing enzyme APOBEC-3F | APOBEC3F | 0.09 |
| INO80 | Chromatin-remodeling ATPase INO80 | INO80 | 0.08 |
| FLI1 | Friend leukemia integration 1 transcription factor | FLI1 | 0.01 |
| RAF1 | RAF proto-oncogene serine/threonine-protein kinase | RAF1 | 0.01 |
| CCNC | Cyclin-C | CCNC | 0.01 |
| ARNTL | Aryl hydrocarbon receptor nuclear translocator-like protein 1 | ARNTL | 0.01 |
| RAD54L | DNA repair and recombination protein RAD54-like | RAD54L | 0.01 |
| CDT1 | DNA replication factor Cdt1 | CDT1 | 0.01 |
| NEIL2 | Endonuclease 8-like 2 | NEIL2 | 0.01 |
| LYZ | Lysozyme C | LYZ | 0.01 |
| PRDM16 | Histone-lysine N-methyltransferase PRDM16 | PRDM16 | 0.01 |
| ZNHIT1 | Zinc finger HIT domain-containing protein 1 | ZNHIT1 | 0.01 |