Skip to main content
. 2022 Nov 15;12(11):5325–5341.

Table 1.

The frequencies of promoter methylation of 40 tumor suppressor genes between ovarian cysts and ovarian cancer cell lines

Gene name Group 1 Group 2 p-value Gene name Group 1 Group 2 p-value


number of methylation cases/all cases Number of methylation cell lines/all cell lines number of methylation cases/all cases Number of methylation cell lines/all cell lines
TP73 0/31 0/6 HIC1 0/31 0/6
CASP8 0/31 0/6 BRCA1 0/31 0/6
VHL 0/31 0/6 TIMP3 6/31 2/6
RARB* 0/31 1/6 0.0212 PRDM2 0/31 0/6
MLH1 0/31 0/6 RUNX3 0/31 3/6 <0.0001
RASSF1A 0/31 5/6 <0.0001 RARB** 0/31 0/6
FHIT 0/31 2/6 0.0009 HLTF 0/31 0/6
APC 0/31 0/6 SCGB3A1 4/31 6/6 <0.0001
ESR1 0/31 1/6 0.0212 ID4 0/31 4/6 <0.0001
CDKN2A 1/31 0/6 TWIST1 0/31 0/6
CDKN2B 8/31 1/6 SFRP4 0/31 2/6 0.0009
DAPK1 0/31 1/6 0.0212 DLC1 1/31 0/6
PTEN 0/31 1/6 0.0212 DLC2 1/31 0/6
CD44 0/31 0/6 SFRP5 0/31 5/6 <0.0001
GSTP1 0/31 1/6 0.0212 BNIP3 1/31 0/6
ATM 0/31 0/6 H2AFX 0/31 0/6
IGSF4 0/31 1/6 0.0212 CCND2 2/31 6/6 <0.0001
CDKN1B 1/31 0/6 CACNA1G 0/31 1/6 0.0212
CHFR 0/31 0/6 TGIF 0/31 0/6
BRCA2 0/31 0/6 BCL2 0/31 0/6
CDH13 0/31 2/6 0.0009 CACNA1A 0/31 3/6 <0.0001

Note: Group 1: ovarian cysts; Group 2: ovarian cancer cell lines;

*

Probe 1: RARB (L10900);

**

Probe 2: RARB (L1698).