Table 1.
The frequencies of promoter methylation of 40 tumor suppressor genes between ovarian cysts and ovarian cancer cell lines
| Gene name | Group 1 | Group 2 | p-value | Gene name | Group 1 | Group 2 | p-value |
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| number of methylation cases/all cases | Number of methylation cell lines/all cell lines | number of methylation cases/all cases | Number of methylation cell lines/all cell lines | ||||
| TP73 | 0/31 | 0/6 | HIC1 | 0/31 | 0/6 | ||
| CASP8 | 0/31 | 0/6 | BRCA1 | 0/31 | 0/6 | ||
| VHL | 0/31 | 0/6 | TIMP3 | 6/31 | 2/6 | ||
| RARB* | 0/31 | 1/6 | 0.0212 | PRDM2 | 0/31 | 0/6 | |
| MLH1 | 0/31 | 0/6 | RUNX3 | 0/31 | 3/6 | <0.0001 | |
| RASSF1A | 0/31 | 5/6 | <0.0001 | RARB** | 0/31 | 0/6 | |
| FHIT | 0/31 | 2/6 | 0.0009 | HLTF | 0/31 | 0/6 | |
| APC | 0/31 | 0/6 | SCGB3A1 | 4/31 | 6/6 | <0.0001 | |
| ESR1 | 0/31 | 1/6 | 0.0212 | ID4 | 0/31 | 4/6 | <0.0001 |
| CDKN2A | 1/31 | 0/6 | TWIST1 | 0/31 | 0/6 | ||
| CDKN2B | 8/31 | 1/6 | SFRP4 | 0/31 | 2/6 | 0.0009 | |
| DAPK1 | 0/31 | 1/6 | 0.0212 | DLC1 | 1/31 | 0/6 | |
| PTEN | 0/31 | 1/6 | 0.0212 | DLC2 | 1/31 | 0/6 | |
| CD44 | 0/31 | 0/6 | SFRP5 | 0/31 | 5/6 | <0.0001 | |
| GSTP1 | 0/31 | 1/6 | 0.0212 | BNIP3 | 1/31 | 0/6 | |
| ATM | 0/31 | 0/6 | H2AFX | 0/31 | 0/6 | ||
| IGSF4 | 0/31 | 1/6 | 0.0212 | CCND2 | 2/31 | 6/6 | <0.0001 |
| CDKN1B | 1/31 | 0/6 | CACNA1G | 0/31 | 1/6 | 0.0212 | |
| CHFR | 0/31 | 0/6 | TGIF | 0/31 | 0/6 | ||
| BRCA2 | 0/31 | 0/6 | BCL2 | 0/31 | 0/6 | ||
| CDH13 | 0/31 | 2/6 | 0.0009 | CACNA1A | 0/31 | 3/6 | <0.0001 |
Note: Group 1: ovarian cysts; Group 2: ovarian cancer cell lines;
Probe 1: RARB (L10900);
Probe 2: RARB (L1698).