Table 2.
The differential percentage of promoter methylation in tumor suppressor genes among ovarian cancer stromal progenitor cells from tissues, ovarian cancer tissues, and ovarian cancer stromal progenitor cells from ascites
| Gene name | Group 1 | Group 2 | Group 3 | p-value | |
|---|---|---|---|---|---|
|
|
|||||
| OCSPC (T) (%) | OC (T) (%) | OCSPC (A) (%) | Group 1 vs 2 | Group 1 vs 2 vs 3 | |
| DLC1 | 5/22 (23%) | 3/11 (27%) | 9/19 (47%) | 0.097 | 0.223 |
| RASSF1A* | 2/22 (9%) | 5/11 (45%) | 8/19 (42%) | 0.014 | 0.026 |
| CDH13 | 0/22 (0%) | 3/11 (27%) | 1/19 (5%) | 0.276 | 0.019 |
| BRCA1 | 0/22 (0%) | 2/11 (18%) | 3/19 (16%) | 0.053 | 0.129 |
| TIMP3 | 3/22 (14%) | 0/11 (0%) | 4/19 (21%) | 0.529 | 0.266 |
| SCGB3A1 | 5/22 (23%) | 2/11 (18%) | 5/19 (26%) | 0.790 | 0.878 |
| ESR1 | 2/22 (9%) | 0/11 (0%) | 2/19 (11%) | 0.877 | 0.551 |
| CDKN2A | 1/22 (5%) | 3/11 (27%) | 2/19 (11%) | 0.463 | 0.154 |
| CCND2** | 12/22 (55%) | 6/11 (55%) | 8/19 (42%) | 0.427 | 0.689 |
| CDKN2B | 9/22 (41%) | 6/11 (55%) | 11/19 (58%) | 0.278 | 0.524 |
| RUNX3 | 4/22 (18%) | 1/11 (9%) | 1/19 (5%) | 0.207 | 0.417 |
| RARB | 3/22 (0%) | 0/11 (0%) | 1/19 (5%) | 0.368 | 0.338 |
| HLTF | 2/22 (9%) | 0/11 (0%) | 0/19 (0%) | 0.178 | 0.242 |
| SFRP4 | 0/22 (0%) | 1/11 (9%) | 0/19 (0%) | NA | 0.150 |
| CACNA1A | 0/22 (0%) | 1/11 (9%) | 1/19 (5%) | 0.639 | 0.883 |
| H2AFX | 0/22 (0%) | 1/11 (9%) | 0/19 (0%) | NA | 0.150 |
| FHIT | 0/22 (%) | 0/11(0%) | 0/19 (0%) | NA | NA |
| ID4 | 0/22 (%) | 0/11(0%) | 0/19 (0%) | NA | NA |
| SFRP5 | 0/22 (0%) | 1/11 (9%) | 0/19 (0%) | NA | 0.150 |
*
represents probe RASSF1A382;
**
represents probe CCND2142.